MED-TECH | Dogs pose potential risks for flu pandemic among humans: study
WASHINGTON — A new study published on Tuesday in the journal mBio revealed that dogs became a potential reservoir for a future influenza pandemic as the influenza virus could jump from pigs into canines and influenza was becoming increasingly diverse in canines.
“The majority of pandemics have been associated with pigs as an intermediate host between avian viruses and human hosts. In this study, we identified influenza viruses jumping from pigs into dogs,” said study investigator Adolfo Garcia-Sastre, Director of the Global Health and Emerging Pathogens Institute of Icahn School of Medicine at Mount Sinai in New York.
Influenza can jump among animal reservoirs where many different strains are located and these reservoirs serve as mixing bowls for the genetic diversity of strains, according to the researchers.
Bird and swine are major reservoirs of viral genetic diversity, and equines and canines have historically been restricted to one or two stable influenza A viruses lineages with no or very limited transmission to human.
Fifteen years ago, researchers documented an influenza virus in a horse jumping into a dog, and this created the first circulating canine influenza viruses.
Five years ago, researchers identified an avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong of China.
“In our study, what we have found is another set of viruses that come from swine that are originally avian in origin, and now they are jumping into dogs and have been reassorted with other viruses in dogs,” said Garcia-Sastre.
“We now have H1N1, H3N2, and H3N8 in dogs. They are starting to interact with each other. This is very reminiscent of what happened in swine ten years before the H1N1 pandemic.”
Also, on the new study, the researchers sequenced the complete genomes of 16 influenza viruses obtained from canines in south China’s Guangxi Zhuang Autonomous Region during 2013 to 2015.
The researchers found that the genomes contained segments from three lineages that circulate in swine in China: North American triple reassortant H3N2, Eurasian avian-like H1N1, and pandemic H1N1.
In addition, the swine-origin H1N1 viruses were transmitted onward in canines and reassorted with the Canine Influenza Virus (CIV) H3N2 viruses that circulate endemically in Asian dogs, producing three novel reassortant CIV genotypes (H1N1r, H1N2r, and H3N2r).
The viruses in the study were collected primarily from pet dogs presenting with respiratory symptoms at veterinary clinics. Dogs in certain regions of China, like Guangxi, are also raised for meat and street dogs roam freely, creating a more complex ecosystem for canine influenza virus transmission.
“The new virus we have identified in our study is H1N1, but it comes from swine and is of avian origin, so it is different antigenically from the new H1N1s that were seen in the pandemic and a different origin as the previous H1N1 seen in humans,” said Dr. Garcia-Sastre.
Future studies will focus on characterizing the virus further and assessing, using human sera, whether humans have existing immunity against canine H1N1 or not.
“If there is a lot of immunity against these viruses, they will represent less of a risk, but we now have one more host in which influenza virus is starting to have a diverse genotypic and phenotypic characteristics, creating diversity in a host which is in very close contact to humans,” said Dr. Garcia-Sastre.
“The diversity in dogs has increased so much now that the type of combinations of viruses that can be created in dogs represent potential risk for a virus to jump to a dog into a human.”