Customize Consent Preferences

We use cookies to help you navigate efficiently and perform certain functions. You will find detailed information about all cookies under each consent category below.

The cookies that are categorized as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site. ... 

Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

MED-TECH | Scientists develop potential therapy for aggressive breast cancer

0

American and Chinese researchers developed an experimental therapy that can reduce the spread of a kind of hard-to-treat breast cancer in a mice study.

breast-cancer

WASHINGTON — American and Chinese researchers developed an experimental therapy that can reduce the spread of a kind of hard-to-treat breast cancer in a mice study.

The study, published on Thursday in the journal Cancer Cell, reported the therapeutic agent that blocks two of the main pathways by which breast cancer cells grow and migrate out of the primary tumor to spread to other organs in the body.

The spread of triple-negative breast cancer is difficult to block, because “if you try one approach, the cancer cells compensate by finding a way to escape,” according to the paper’s senior author Kang Yibin, professor of molecular biology at Princeton University.

This kind of breast caner is highly aggressive and it occurs in 12 to 17 percent of all breast cancer cases. It gets the name from the lack of three major biological targets that are used to find and kill cancer cells.

Patients with triple-negative breast cancer have high rates of recurrence and fewer treatment options, according to the researchers.

“With this new approach, the treatment blocks both pathways at the same time. It is like having one stone that kills two birds,” said Kang.

The researchers found that the new agent called Tinagl1 could inhibit distinctly two main pathways that contribute to triple-negative breast cancer’s aggressiveness and ability to resist treatments.

The agent can stop action of a tumor-promoting protein known as EGFR and also target molecules called integrins that are involved in regulating cellular transformation into tumors, according to the study.

The researchers found that high expression of Tinagl1 in mouse cancer cells produced slower-growing tumors that were less likely to metastasize to the lung.

They also administered Tinagl1 protein to mice with breast cancer and found that treatment for seven weeks significantly inhibited primary tumor growth and spontaneous lung metastasis.

Researchers from Fudan University Shanghai Cancer Center and Rutgers Cancer Institute of New Jersey also contributed to the study.

Leave a Reply

Your email address will not be published. Required fields are marked *